Effectiveness and safety of didanosine, lamivudine and efavirenz versus zidovudine, lamivudine and efavirenz for the initial treatment of HIV-infected patients from the Spanish VACH cohort | Zendy

Manuel Crespo | Zendy; Esteban Ribera | Zendy; Ignacio Suárez-Lozano | Zendy; Peré Domingo | Zendy; Enric Pedrol | Zendy; José LópezAldeguer | Zendy; Agustín Matías Muñoz | Zendy; Consuelo Viladés | Zendy; T Sánchez | Zendy; Pompeyo Viciana | Zendy; Ramón Teira | Zendy; Ma Luisa Garcia-Alcalde | Zendy; A. Vergara | Zendy; Fernando Lozano | Zendy; MJ Galindo | Zendy; J. Cosin | Zendy; Bernardino Roca | Zendy; A. Terrón | Zendy; Paloma Geijo | Zendy; Francesc Vidal | Zendy; Myriam Garrido | Zendy

Open Access

Effectiveness and safety of didanosine, lamivudine and efavirenz versus zidovudine, lamivudine and efavirenz for the initial treatment of HIV-infected patients from the Spanish VACH cohort

Author(s) -

Manuel Crespo,

Esteban Ribera,

Ignacio Suárez-Lozano,

Peré Domingo,

Enric Pedrol,

José LópezAldeguer,

Agustín Matías Muñoz,

Consuelo Viladés,

T Sánchez,

Pompeyo Viciana,

Ramón Teira,

Ma Luisa Garcia-Alcalde,

A. Vergara,

Fernando Lozano,

MJ Galindo,

J. Cosin,

Bernardino Roca,

A. Terrón,

Paloma Geijo,

Francesc Vidal,

Myriam Garrido

Publication year - 2008

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/dkn450

Subject(s) - efavirenz , lamivudine , didanosine , zidovudine , medicine , stavudine , gastroenterology , viral load , virology , viral disease , human immunodeficiency virus (hiv) , antiretroviral therapy , virus , hepatitis b virus

Preliminary data suggest that a once-daily combination of lamivudine, didanosine and efavirenz is an effective alternative regimen for antiretroviral-naive HIV-1-infected patients. However, data from randomized trials comparing this combination versus standard first-line regimens are not available yet. In an observational study, we analyse the efficacy and tolerability of didanosine plus lamivudine and efavirenz versus zidovudine plus lamivudine and efavirenz in a cohort of therapy naive patients.

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