Unusual resistance patterns in macrolide-resistant Streptococcus pyogenes harbouring erm(A) | Zendy

Surbhi MalhotraKumar | Zendy; Annarita Mazzariol | Zendy; Liesbet Van Heirstraeten | Zendy; Christine Lammens | Zendy; Peter De Rijk | Zendy; Giuseppe Cornaglia | Zendy; Herman Goossens | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Unusual resistance patterns in macrolide-resistant Streptococcus pyogenes harbouring erm(A)

Author(s) -

Surbhi MalhotraKumar,

Annarita Mazzariol,

Liesbet Van Heirstraeten,

Christine Lammens,

Peter De Rijk,

Giuseppe Cornaglia,

Herman Goossens

Publication year - 2008

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/dkn432

Subject(s) - streptococcus pyogenes , microbiology and biotechnology , biology , streptococcus pneumoniae , medicine , antibiotics , bacteria , genetics , staphylococcus aureus

We identified erm(A)-harbouring Streptococcus pyogenes that expressed three variant phenotypes: (1) low-level resistance to erythromycin (MICs 1-4 mg/L) but high azithromycin MICs in absolute terms (16-64 mg/L; n=6); (2) same as (1) but with a high clindamycin MIC (256 mg/L; n=1); and (3) high-level constitutive MLS (cMLS) resistance (n=1). Here we analysed the genetic basis of these novel phenotypes.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research