Different effects of telithromycin on MUC5AC production induced by human neutrophil peptide-1 or lipopolysaccharide in NCI-H292 cells compared with azithromycin and clarithromycin | Zendy

Hiroshi Ishimoto | Zendy; Hiroshi Mukae | Zendy; Noriho Sakamoto | Zendy; Misato Amenomori | Zendy; Takeshi Kitazaki | Zendy; Yoshifumi Imamura | Zendy; Hanako Fujita | Zendy; Hiroshi Ishii | Zendy; Seiko Nakayama | Zendy; K. Yanagihara | Zendy; Shigekatsu Kohno | Zendy

Open Access

Different effects of telithromycin on MUC5AC production induced by human neutrophil peptide-1 or lipopolysaccharide in NCI-H292 cells compared with azithromycin and clarithromycin

Author(s) -

Hiroshi Ishimoto,

Hiroshi Mukae,

Noriho Sakamoto,

Misato Amenomori,

Takeshi Kitazaki,

Yoshifumi Imamura,

Hanako Fujita,

Hiroshi Ishii,

Seiko Nakayama,

K. Yanagihara,

Shigekatsu Kohno

Publication year - 2008

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/dkn427

Subject(s) - diffuse panbronchiolitis , clarithromycin , azithromycin , antibiotics , cystic fibrosis , macrolide antibiotics , mucin , telithromycin , medicine , erythromycin , microbiology and biotechnology , lipopolysaccharide , antimicrobial , peptide , immunology , pharmacology , biology , pathology , biochemistry

Mucus hypersecretion is a prominent feature in patients with chronic respiratory tract infections such as cystic fibrosis and diffuse panbronchiolitis, and the clinical effectiveness of macrolide antibiotics has been reported in these patients. Because human neutrophil peptide-1 (HNP-1), an antimicrobial peptide in neutrophils, exists in high concentrations in the airway fluid of these patients, we examined the direct effect of HNP-1 on MUC5AC mucin production using NCI-H292 cells. The effects of macrolide antibiotics on the response were also examined.

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