Usefulness of monitoring ribavirin plasma concentrations to improve treatment response in patients with chronic hepatitis C | Zendy

Judit Morelló | Zendy; Sonia RodríguezNóvoa | Zendy; Inmaculada Jiménez-Nàcher | Zendy; Vincent Soriano | Zendy

Open Access

Usefulness of monitoring ribavirin plasma concentrations to improve treatment response in patients with chronic hepatitis C

Author(s) -

Judit Morelló,

Sonia RodríguezNóvoa,

Inmaculada Jiménez-Nàcher,

Vincent Soriano

Publication year - 2008

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/dkn421

Subject(s) - ribavirin , medicine , dosing , therapeutic index , therapeutic drug monitoring , hepatitis c , pharmacology , pegylated interferon , chronic hepatitis , gastroenterology , drug , immunology , virus

Ribavirin in combination with pegylated interferon alpha is the current standard treatment for chronic hepatitis C. Adequate exposure to ribavirin seems crucial for achieving the best virological response. However, anaemia is a frequent, dose-dependent limiting side effect of ribavirin use. Therefore, therapeutic drug monitoring of ribavirin plasma concentrations could be a useful tool for individualizing ribavirin dosing. Herein, we review the relationship between ribavirin plasma concentrations and both virological response and toxicity, in order to define an optimal therapeutic range for ribavirin.

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