Phase-dependent antifungal activity against Aspergillus fumigatus developing multicellular filamentous biofilms | Zendy

Eilidh Mowat | Zendy; Sue Lang | Zendy; Craig Williams | Zendy; Elaine McCulloch | Zendy; B Jones | Zendy; Gordon Ramage | Zendy

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Phase-dependent antifungal activity against Aspergillus fumigatus developing multicellular filamentous biofilms

Author(s) -

Eilidh Mowat,

Sue Lang,

Craig Williams,

Elaine McCulloch,

B Jones,

Gordon Ramage

Publication year - 2008

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/dkn402

Subject(s) - voriconazole , caspofungin , aspergillus fumigatus , amphotericin b , microbiology and biotechnology , aspergillosis , biology , antifungal , immunology

Aspergillus fumigatus undergoes morphological transition throughout its growth and development. These changes have direct implications for the effectiveness of antifungal treatment. Here we report the in vitro antifungal activity of voriconazole, amphotericin B and caspofungin against three specific phases of multicellular development of A. fumigatus.

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