Detection of low-frequency K103N mutants after unstructured discontinuation of efavirenz in the presence of the CYP2B6 516 TT polymorphism | Zendy

A. Garcia-Diaz | Zendy; C. Blok | Zendy; Sara Madge | Zendy; Clare Booth | Zendy; Mervyn Tyrer | Zendy; S. Bonora | Zendy; Tabitha Mahungu | Zendy; Andrew Owen | Zendy; M. Johnson | Zendy; Anna María Geretti | Zendy

Open Access

Detection of low-frequency K103N mutants after unstructured discontinuation of efavirenz in the presence of the CYP2B6 516 TT polymorphism

Author(s) -

A. Garcia-Diaz,

C. Blok,

Sara Madge,

Clare Booth,

Mervyn Tyrer,

S. Bonora,

Tabitha Mahungu,

Andrew Owen,

M. Johnson,

Anna María Geretti

Publication year - 2008

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/dkn374

Subject(s) - efavirenz , virology , drug resistance , viral load , population , reverse transcriptase , biology , nevirapine , discontinuation , medicine , immunology , virus , antiretroviral therapy , genetics , polymerase chain reaction , gene , environmental health

To measure antiretroviral drug plasma levels in newly diagnosed HIV-1 seropositive persons who presented with an undetectable plasma HIV-1 RNA load but gave no history of antiretroviral drug exposure and to determine the impact of interrupting undisclosed or unknown antiretroviral therapy on the emergence of drug resistance.

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