Consequences of daptomycin-mediated membrane damage in Staphylococcus aureus | Zendy

Joanne K. Hobbs | Zendy; Keith Miller | Zendy; Alex J. O’Neill | Zendy; I. Chopra | Zendy

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Consequences of daptomycin-mediated membrane damage in Staphylococcus aureus

Author(s) -

Joanne K. Hobbs,

Keith Miller,

Alex J. O’Neill,

I. Chopra

Publication year - 2008

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/dkn321

Subject(s) - daptomycin , depolarization , membrane , intracellular , chemistry , biophysics , staphylococcus aureus , membrane potential , cell membrane , biochemistry , biology , bacteria , vancomycin , genetics

The proposed lethal action of daptomycin on Staphylococcus aureus results from the loss of K(+) and membrane depolarization. However, whether these events alone cause cell death has been questioned. We sought to determine whether other consequences of daptomycin-mediated membrane damage may contribute to cell death.

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