Antileishmanial activity mediated by apoptosis and structure-based target study of peganine hydrochloride dihydrate: an approach for rational drug design | Zendy

Pragya Misra | Zendy; Tanvir Khaliq | Zendy; Anshuman Dixit | Zendy; Souvik Sengupta | Zendy; Mukesh Samant | Zendy; Shraddha Kumari | Zendy; Awanish Kumar | Zendy; Pramod Kumar Kushawaha | Zendy; Hemanta K. Majumder | Zendy; Anil K. Saxena | Zendy; Tadigoppula Narender | Zendy; Anuradha Dube | Zendy

Open Access

Antileishmanial activity mediated by apoptosis and structure-based target study of peganine hydrochloride dihydrate: an approach for rational drug design

Author(s) -

Pragya Misra,

Tanvir Khaliq,

Anshuman Dixit,

Souvik Sengupta,

Mukesh Samant,

Shraddha Kumari,

Awanish Kumar,

Pramod Kumar Kushawaha,

Hemanta K. Majumder,

Anil K. Saxena,

Tadigoppula Narender,

Anuradha Dube

Publication year - 2008

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/dkn319

Subject(s) - topoisomerase , leishmania donovani , apoptosis , biology , biochemistry , dna , microbiology and biotechnology , chemistry , pharmacology , immunology , leishmaniasis , visceral leishmaniasis

The aim of this study was to resolve the putative pathway responsible for death induced by peganine hydrochloride dihydrate isolated from Peganum harmala seeds at cellular, structural and molecular level in Leishmania donovani, a causative agent of fatal visceral leishmaniasis.

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