Evaluation of aminocandin and caspofungin against Candida glabrata including isolates with reduced caspofungin susceptibility | Zendy

G. E. Brzankalski | Zendy; Laura K. Najvar | Zendy; Nathan P. Wiederhold | Zendy; Rosie Bocanegra | Zendy; Annette W. Fothergill | Zendy; Michael G. Rinaldi | Zendy; T. F. Pattterson | Zendy; John R. Graybill | Zendy

Open Access

Evaluation of aminocandin and caspofungin against Candida glabrata including isolates with reduced caspofungin susceptibility

Author(s) -

G. E. Brzankalski,

Laura K. Najvar,

Nathan P. Wiederhold,

Rosie Bocanegra,

Annette W. Fothergill,

Michael G. Rinaldi,

T. F. Pattterson,

John R. Graybill

Publication year - 2008

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/dkn304

Subject(s) - caspofungin , echinocandin , echinocandins , candida glabrata , microbiology and biotechnology , potency , in vivo , in vitro , biology , pharmacology , antifungal , voriconazole , fluconazole , biochemistry

Aminocandin is an investigational echinocandin with excellent activity against Candida species, including Candida albicans and Candida tropicalis. However, few data are available for this agent versus Candida glabrata. We compared the in vitro potency and in vivo efficacy of aminocandin and caspofungin against clinical isolates of C. glabrata including those with reduced caspofungin susceptibility (MIC > 2 mg/L).

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research