Accumulation of CVIET Pfcrt allele of Plasmodium falciparum in placenta of pregnant women living in an urban area of Dakar, Senegal | Zendy

Makhtar Niang | Zendy; Laurence Marrama | Zendy; M. T. Ekala | Zendy; Gueye Mamour Gaye Alioune | Zendy; Adama Tall | Zendy; Jean Louis Ndiaye | Zendy; Demba Sarr | Zendy; Jean-Marie Dangou | Zendy; JeanYves Le Hesran | Zendy; Christiane Bouchier | Zendy; O. Mercereau-Puijalon | Zendy; Ronan Jambou | Zendy

Open Access

Accumulation of CVIET Pfcrt allele of Plasmodium falciparum in placenta of pregnant women living in an urban area of Dakar, Senegal

Author(s) -

Makhtar Niang,

Laurence Marrama,

M. T. Ekala,

Gueye Mamour Gaye Alioune,

Adama Tall,

Jean Louis Ndiaye,

Demba Sarr,

Jean-Marie Dangou,

JeanYves Le Hesran,

Christiane Bouchier,

O. Mercereau-Puijalon,

Ronan Jambou

Publication year - 2008

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/dkn299

Subject(s) - placenta , malaria , biology , genotyping , plasmodium falciparum , chloroquine , chemoprophylaxis , pregnancy , immunology , genotype , fetus , medicine , genetics , gene

Chemoprophylaxis is recommended during pregnancy to reduce the risk of placental infection. However, in areas with increasing drug resistance, it can trigger selection of resistant parasites in the placenta and increase the frequency of placental malaria. The objective of this study was to analyse the selection of drug-resistant parasites in the placenta in an area where chloroquine was still recommended as prophylaxis.

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