Telavancin and vancomycin pharmacodynamics with Staphylococcus aureus in an in vitro dynamic model
Author(s) -
Irene Yu Lubenko,
Ele. Strukova,
Maria V. Smirnova,
Sergey N. Vostrov,
Yury A. Portnoy,
Stephen H. Zinner,
Alexander A. Firsov
Publication year - 2008
Publication title -
journal of antimicrobial chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.124
H-Index - 194
eISSN - 1460-2091
pISSN - 0305-7453
DOI - 10.1093/jac/dkn288
Subject(s) - staphylococcus aureus , pharmacodynamics , vancomycin , microbiology and biotechnology , minimum inhibitory concentration , antibiotics , methicillin resistant staphylococcus aureus , area under the curve , pharmacokinetics , medicine , pharmacology , biology , bacteria , genetics
The aim of this study was to compare the pharmacodynamics of telavancin (TLV) and vancomycin (VAN) with Staphylococcus aureus. Their concentrations were simulated between the MIC and the mutant prevention concentration (MPC), and above the MPC.
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