Cytokine and sex hormone effects on zidovudine- and lamivudine-triphosphate concentrations in vitro | Zendy

Peter L. Anderson | Zendy; Tekoa L. King | Zendy; J.-H. Zheng | Zendy; Samantha MaWhinney | Zendy

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Cytokine and sex hormone effects on zidovudine- and lamivudine-triphosphate concentrations in vitro

Author(s) -

Peter L. Anderson,

Tekoa L. King,

J.-H. Zheng,

Samantha MaWhinney

Publication year - 2008

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/dkn247

Subject(s) - zidovudine , lamivudine , peripheral blood mononuclear cell , medicine , endocrinology , testosterone (patch) , cytokine , pharmacology , chemistry , immunology , in vitro , biochemistry , human immunodeficiency virus (hiv) , virus , viral disease , hepatitis b virus

Elevated zidovudine- and lamivudine-triphosphates have been observed in peripheral blood mononuclear cells (PBMCs) from females versus males and in patients with high inflammatory states versus lower inflammatory states. Consistent with high triphosphate exposures, these same patient groups also experience elevated rates of toxicity, including lipoatrophy. The purpose of this study was to evaluate the effects of oestradiol, progesterone and testosterone as well as tumour necrosis factor (TNF)-alpha and interferon (IFN)-alpha on zidovudine- and lamivudine-triphosphates in PBMCs and, for the cytokines, in 3T3-L1 adipocytes.

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