In vitro and in vivo antimycobacterial activities of ketone and amide derivatives of quinoxaline 1,4-di-N-oxide | Zendy

Raquel Villar | Zendy; Esther Vicente | Zendy; Beatriz Solano | Zendy; Silvia PérezSilanes | Zendy; Ignacio Aldana | Zendy; Joseph A. Maddry | Zendy; Anne J. Lenaerts | Zendy; Scott G. Franzblau | Zendy; SangHyun Cho | Zendy; Antonio Monge | Zendy; Robert C. Goldman | Zendy

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In vitro and in vivo antimycobacterial activities of ketone and amide derivatives of quinoxaline 1,4-di-N-oxide

Author(s) -

Raquel Villar,

Esther Vicente,

Beatriz Solano,

Silvia PérezSilanes,

Ignacio Aldana,

Joseph A. Maddry,

Anne J. Lenaerts,

Scott G. Franzblau,

SangHyun Cho,

Antonio Monge,

Robert C. Goldman

Publication year - 2008

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/dkn214

Subject(s) - mycobacterium tuberculosis , in vivo , microbiology and biotechnology , isoniazid , pharmacology , quinoxaline , antimycobacterial , chemistry , tuberculosis , active metabolite , in vitro , drug resistance , medicine , biology , pharmacokinetics , biochemistry , organic chemistry , pathology

To evaluate a novel series of quinoxaline 1,4-di-N-oxides for in vitro activity against Mycobacterium tuberculosis and for efficacy in a mouse model of tuberculosis (TB).

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