Pharmacokinetic analysis to assess forgiveness of boosted saquinavir regimens for missed or late dosing | Zendy

Laura Dickinson | Zendy; Marta Boffito | Zendy; S. H. Khoo | Zendy; Adrian Schütz | Zendy; Leon Aarons | Zendy; Anton Pozniak | Zendy; David Back | Zendy

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Pharmacokinetic analysis to assess forgiveness of boosted saquinavir regimens for missed or late dosing

Author(s) -

Laura Dickinson,

Marta Boffito,

S. H. Khoo,

Adrian Schütz,

Leon Aarons,

Anton Pozniak,

David Back

Publication year - 2008

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/dkn187

Subject(s) - saquinavir , pharmacokinetics , ritonavir , dosing , trough concentration , medicine , regimen , cmax , pharmacology , population , human immunodeficiency virus (hiv) , viral load , virology , antiretroviral therapy , environmental health

One potential concern of once-daily protease inhibitor administration is low trough concentrations and ultimately the 'forgiveness' or robustness in comparison with the originally licensed twice-daily dose. To give an estimation of 'forgiveness', we determined the length of time plasma drug concentrations were below target in HIV-infected patients receiving saquinavir/ritonavir regimens.

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