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Recurrence of heterogeneous methicillin-resistant Staphylococcus aureus (MRSA) among the MRSA clinical isolates in a Japanese university hospital
Author(s) -
Kozue Kishii,
Ito T,
Shinya Watanabe,
Katsuko Okuzumi,
Keiichi Hiramatsu
Publication year - 2008
Publication title -
journal of antimicrobial chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.124
H-Index - 194
eISSN - 1460-2091
pISSN - 0305-7453
DOI - 10.1093/jac/dkn186
Subject(s) - multilocus sequence typing , sccmec , methicillin resistant staphylococcus aureus , staphylococcus aureus , microbiology and biotechnology , antibiotics , biology , typing , genotype , meticillin , antibiotic resistance , staphylococcal infections , cefazolin , population , medicine , antibacterial agent , micrococcaceae , genetics , gene , bacteria , environmental health
In the early 1980s, heterogeneous methicillin-resistant Staphylococcus aureus (hetero-MRSA) strains were predominant in the University of Tokyo Hospital. But, in the 1990s, they were completely substituted by homogeneously highly methicillin-resistant S. aureus (homo-MRSA) strains. Since 2000, however, we started observing an increase in MRSA strains with low cefazolin MICs (MRCLSA). This study was performed to understand the phenomenon by characterization of the 'cefazolin-susceptible' MRSA strains.

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