Plant phenolic compounds as ethidium bromide efflux inhibitors in Mycobacterium smegmatis | Zendy

Doris Lechner | Zendy; Simon Gibbons | Zendy; Franz Bučar | Zendy

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Plant phenolic compounds as ethidium bromide efflux inhibitors in Mycobacterium smegmatis

Author(s) -

Doris Lechner,

Simon Gibbons,

Franz Bučar

Publication year - 2008

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/dkn178

Subject(s) - efflux , ethidium bromide , mycobacterium smegmatis , biochanin a , isoflavonoid , microbiology and biotechnology , pharmacology , mycobacterium tuberculosis , chemistry , biology , biochemistry , flavonoid , genistein , tuberculosis , medicine , daidzein , dna , pathology , antioxidant , endocrinology

One-third of the world's population is infected with the dormant tuberculosis bacillus, and there have been no new antimycobacterial compounds with new modes of action for over 30 years. Extensively drug-resistant tuberculosis is resistant to first- and second-line drugs, which can have severe side effects, and requires the breakthrough of new antituberculotics and resistance-modifying agents. Efflux pumps can cause multidrug resistance and have recently evoked much interest as promising new targets in antimicrobial therapy.

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