English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Plus monthly

Global: Zendy Tools annual

Global: Zendy Tools monthly

Global: Zendy Free Plan

after exposure to vancomycin, suggesting the same underlying resistance mechanism. 16 During therapy with daptomycin for S. aureus bacteraemia and endocarditis, 16% of the patients failed with a persistent or relapsing infection with increasing isolate MICs. Most of these failures were in deep-seated infections for which a necessary surgical intervention was not performed. 17 In the case of Enterococcus, either a chronic indwelling line or persistent focus of infection was reported for all but two of the seven reported cases of daptomycin clinical treatment failures, and non-susceptibility developed on treatment after an average of 19 days. 4 – 10 The mechanisms of non-susceptibility to daptomycin are thus diverse and not completely understood. Increasing MICs in the setting of pre-exposure to either vancomycin or daptomycin and/or evidence of a persistent focus of infection seem to be a frequent occurrence for clinical failures among both S. aureus and Enterococcus species. Despite lack of experimental data, it is plausible that the mechanisms that explain enterococcal non-susceptibility parallel those for S. aureus. The use of daptomy-cin in patients with prior prolonged vancomycin or daptomycin therapy, or with a focus of infection that cannot be removed, should be undertaken with caution, as clinical failure can occur.

Severe hypokalaemia caused by flucloxacillin