Polyene susceptibility is dependent on nitrogen source in the opportunistic pathogen Candida albicans | Zendy

Brian G. Oliver | Zendy; P.M. Silver | Zendy; Theodore C. White | Zendy

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Polyene susceptibility is dependent on nitrogen source in the opportunistic pathogen Candida albicans

Author(s) -

Brian G. Oliver,

P.M. Silver,

Theodore C. White

Publication year - 2008

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/dkn101

Subject(s) - nystatin , candida albicans , microbiology and biotechnology , polyene , ergosterol , amphotericin b , sterol , corpus albicans , aspergillus fumigatus , biology , biochemistry , chemistry , antibiotics , cholesterol , antifungal

Polyene antifungal drugs, including amphotericin B or nystatin, target ergosterol in the fungal plasma membrane and are used to treat systemic, vaginal and oral fungal infections. In the oral cavity, the available nitrogen sources are primarily in the form of proteins, which are poor nitrogen sources. This study evaluates the effect of protein as a nitrogen source on drug susceptibilities.

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