Thioridazine and chlorpromazine inhibition of ethidium bromide efflux in Mycobacterium avium and Mycobacterium smegmatis | Zendy

Liliana Rodrigues | Zendy; Dirk Wagner | Zendy; Miguel Viveiros | Zendy; Dioniso de Souza Sampaio | Zendy; Isabel Couto | Zendy; Martina Vavra | Zendy; Winfried V. Kern | Zendy; Leonard Amaral | Zendy

Open Access

Thioridazine and chlorpromazine inhibition of ethidium bromide efflux in Mycobacterium avium and Mycobacterium smegmatis

Author(s) -

Liliana Rodrigues,

Dirk Wagner,

Miguel Viveiros,

Dioniso de Souza Sampaio,

Isabel Couto,

Martina Vavra,

Winfried V. Kern,

Leonard Amaral

Publication year - 2008

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/dkn070

Subject(s) - ethidium bromide , mycobacterium smegmatis , efflux , thioridazine , verapamil , chemistry , mycobacterium , antimycobacterial , chlorpromazine , microbiology and biotechnology , pharmacology , biochemistry , biology , bacteria , mycobacterium tuberculosis , calcium , medicine , genetics , dna , tuberculosis , organic chemistry , pathology

Therapy of AIDS patients infected with Mycobacterium avium is problematic due to its intrinsic resistance to antibiotics. We have characterized the efflux pump activity of M. avium wild-type strain through an automated fluorometric method and correlated it with intrinsic resistance to antibiotics.

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