Comparison of the dose-dependent activity and paradoxical effect of caspofungin and micafungin in a neutropenic murine model of invasive pulmonary aspergillosis | Zendy

Russell E. Lewis | Zendy; N. D. Albert | Zendy; Dimitrios P. Kontoyiannis | Zendy

Open Access

Comparison of the dose-dependent activity and paradoxical effect of caspofungin and micafungin in a neutropenic murine model of invasive pulmonary aspergillosis

Author(s) -

Russell E. Lewis,

N. D. Albert,

Dimitrios P. Kontoyiannis

Publication year - 2008

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/dkn069

Subject(s) - micafungin , caspofungin , echinocandins , echinocandin , pharmacology , aspergillosis , pharmacodynamics , dosing , medicine , pharmacokinetics , amphotericin b , immunology , antifungal , dermatology , fluconazole

The safety and concentration-dependent pharmacodynamic characteristics of the echinocandins make them ideal candidates for dosage escalation in the treatment of aspergillosis. However, paradoxical attenuation of antifungal activity with increasing doses has been reported for some echinocandins in experimental models of invasive pulmonary aspergillosis (IPA).

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