Pharmacokinetics of azithromycin in serum, bronchial washings, alveolar macrophages and lung tissue following a single oral dose of extended or immediate release formulations of azithromycin | Zendy

Marco Lucchi | Zendy; Bharat Damle | Zendy; Annie Fang | Zendy; Pascal J. de Caprariis | Zendy; A Mussi | Zendy; Sonia P. Sanchez | Zendy; Giuseppe Pasqualetti | Zendy; Mario Del Tacca | Zendy

Open Access

Pharmacokinetics of azithromycin in serum, bronchial washings, alveolar macrophages and lung tissue following a single oral dose of extended or immediate release formulations of azithromycin

Author(s) -

Marco Lucchi,

Bharat Damle,

Annie Fang,

Pascal J. de Caprariis,

A Mussi,

Sonia P. Sanchez,

Giuseppe Pasqualetti,

Mario Del Tacca

Publication year - 2008

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/dkn032

Subject(s) - azithromycin , pharmacokinetics , medicine , bronchoalveolar lavage , lung , oral administration , antibacterial agent , pharmacology , alveolar macrophage , gastroenterology , pathology , antibiotics , biology , microbiology and biotechnology , macrophage , in vitro , biochemistry

Antibacterial efficacy of azithromycin could be improved by achieving higher concentrations at the sites of infection. Azithromycin extended release (azithromycin-ER) formulation was developed to enable a higher dosage of 2 g to be administered as a single oral dose without decreasing the safety profile. The aim of this study was to compare the pharmacokinetics of azithromycin in serum, epithelial lining fluid (ELF), alveolar macrophages (AMs) and lung tissue following a single oral dose of azithromycin-ER or azithromycin immediate release (azithromycin-IR) formulation.

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