Impact of CYP2B6 983T>C polymorphism on non-nucleoside reverse transcriptase inhibitor plasma concentrations in HIV-infected patients | Zendy

Christoph Wyen | Zendy; Heidy Hendra | Zendy; M. Vogel | Zendy; Christian Hoffmann | Zendy; Heribert Knechten | Zendy; Norbert H. Brockmeyer | Zendy; Johannes R. Bogner | Zendy; JK Rockstroh | Zendy; Stefan Eßer | Zendy; H. Jaeger | Zendy; Thomas Harrer | Zendy; Stefan Mauss | Zendy; Jan van Lunzen | Zendy; Nicole Skoetz | Zendy; Alexander Jetter | Zendy; C. Groneuer | Zendy; Gerd Fätkenheuer | Zendy; Saye Khoo | Zendy; David Egan | Zendy; David Back | Zendy; Andrew Owen | Zendy

Open Access

Impact of CYP2B6 983T>C polymorphism on non-nucleoside reverse transcriptase inhibitor plasma concentrations in HIV-infected patients

Author(s) -

Christoph Wyen,

Heidy Hendra,

M. Vogel,

Christian Hoffmann,

Heribert Knechten,

Norbert H. Brockmeyer,

Johannes R. Bogner,

JK Rockstroh,

Stefan Eßer,

H. Jaeger,

Thomas Harrer,

Stefan Mauss,

Jan van Lunzen,

Nicole Skoetz,

Alexander Jetter,

C. Groneuer,

Gerd Fätkenheuer,

Saye Khoo,

David Egan,

David Back,

Andrew Owen

Publication year - 2008

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/dkn029

Subject(s) - efavirenz , nevirapine , cyp2b6 , genotype , reverse transcriptase inhibitor , pharmacology , medicine , genotyping , pharmacogenetics , gastroenterology , biology , virology , sida , viral load , genetics , human immunodeficiency virus (hiv) , antiretroviral therapy , viral disease , cytochrome p450 , metabolism , cyp3a4 , gene

The aim of this study was to investigate the frequency of CYP2B6 polymorphisms (according to ethnicity) and the influence of heterozygosity and homozygosity on plasma concentrations of efavirenz and nevirapine.

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