Hepatitis B virus escape mutants induced by antiviral therapy | Zendy

Julie Sheldon | Zendy; Vincent Soriano | Zendy

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Hepatitis B virus escape mutants induced by antiviral therapy

Author(s) -

Julie Sheldon,

Vincent Soriano

Publication year - 2008

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/dkn014

Subject(s) - virology , hepatitis b virus , antigenicity , biology , virus , antigen , hepadnaviridae , hepatitis b , antibody , reverse transcriptase , mutant , viral envelope , orthohepadnavirus , gene , immunology , polymerase chain reaction , genetics

The hepatitis B virus (HBV) polymerase and envelope genes overlap in such a way that resistance mutations to antiviral agents in the reverse transcriptase gene may affect the antigenicity of the HBV surface antigen. Mutant viruses may escape serological diagnosis using specific anti-HBV surface antigen antibodies, causing occult forms of chronic hepatitis B. Moreover, these HBV strains may evade vaccine protection, representing a public health challenge. Thus, the circulation of HBVs encoding envelope mutations selected by antiviral agents requires close monitoring.

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