Efficacy of combination of chlorhexidine and protamine sulphate against device-associated pathogens | Zendy

Rabih O. Darouiche | Zendy; Mohammad D. Mansouri | Zendy; Purushottam V. Gawande | Zendy; Srinivasa Madhyastha | Zendy

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Efficacy of combination of chlorhexidine and protamine sulphate against device-associated pathogens

Author(s) -

Rabih O. Darouiche,

Mohammad D. Mansouri,

Purushottam V. Gawande,

Srinivasa Madhyastha

Publication year - 2008

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/dkn006

Subject(s) - chlorhexidine , protamine , microbiology and biotechnology , anti infective agents , protamine sulfate , medicine , chemistry , biology , antimicrobial , dentistry , heparin

The objectives of this study were to examine: (i) the potential in vitro synergy of combining protamine sulphate (PS) with chlorhexidine (CHX); (ii) the in vitro spectrum and durability of antimicrobial activity of CHX + PS-coated catheters; and (iii) the in vivo efficacy of CHX + PS-coated catheters in comparison with silver-hydrogel-coated and uncoated catheters.

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