Open AccessInfluences of dosage regimen and co-administration of low-molecular weight proteins and basic peptides on renal accumulation of arbekacin in mice
Author(s) -
Shinya Murakami,
Junya Nagai,
Kenji Fujii,
R Yumoto,
Mikihisa Takano
Publication year - 2008
Publication title -
journal of antimicrobial chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.124
H-Index - 194
eISSN - 1460-2091
pISSN - 0305-7453
DOI - 10.1093/jac/dkm512
Subject(s) - medicine , nephrotoxicity , pharmacology , aminoglycoside , renal function , antibiotics , kidney , chemistry , biochemistry
The objectives of this study were to characterize renal accumulation of arbekacin, an aminoglycoside antibiotic for treatment of infections with methicillin-resistant Staphylococcus aureus, and to modulate renal uptake of arbekacin, leading to prevention of arbekacin-induced nephrotoxicity.
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