Subinhibitory concentrations of telithromycin, clarithromycin and azithromycin reduce methicillin-resistant Staphylococcus aureus coagulase in vitro and in vivo | Zendy

Katsunori Yanagihara | Zendy; Yoshitomo Morinaga | Zendy; Shigeki Nakamura | Zendy; Masafumi Seki | Zendy; Kohichi Izumikawa | Zendy; Hiroshi Kakeya | Zendy; Yoshihiro Yamamoto | Zendy; Yohei Yamada | Zendy; S Kamihira | Zendy; S Kohno | Zendy

Open Access

Subinhibitory concentrations of telithromycin, clarithromycin and azithromycin reduce methicillin-resistant Staphylococcus aureus coagulase in vitro and in vivo

Author(s) -

Katsunori Yanagihara,

Yoshitomo Morinaga,

Shigeki Nakamura,

Masafumi Seki,

Kohichi Izumikawa,

Hiroshi Kakeya,

Yoshihiro Yamamoto,

Yohei Yamada,

S Kamihira,

S Kohno

Publication year - 2008

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/dkm507

Subject(s) - telithromycin , clarithromycin , azithromycin , microbiology and biotechnology , ketolide , antibiotics , antibacterial agent , streptococcus pneumoniae , coagulase , staphylococcus aureus , medicine , in vivo , biology , bacteria , staphylococcus , genetics

Subinhibitory levels of clarithromycin and azithromycin have been shown to reduce the activity of bacterial virulence factors, but few studies have examined the effects of subinhibitory levels of telithromycin. Here, we examined the effects of telithromycin, clarithromycin and azithromycin on methicillin-resistant Staphylococcus aureus (MRSA) coagulase in vitro. We also examined the effects of these antibiotics on bacterial survival in a murine model of pulmonary infection, in which the number of bacteria in the lung correlates with the coagulase titre.

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