The role of vitamin B6 in the prevention of haematological toxic effects of linezolid in patients with cancer | Zendy

S. Youssef | Zendy; Ray Hachem | Zendy; Roy F. Chemaly | Zendy; Javier A. Adachi | Zendy; Jianming Ying | Zendy; K. V. I. Rolston | Zendy; Issam Raad | Zendy

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The role of vitamin B6 in the prevention of haematological toxic effects of linezolid in patients with cancer

Author(s) -

S. Youssef,

Ray Hachem,

Roy F. Chemaly,

Javier A. Adachi,

Jianming Ying,

K. V. I. Rolston,

Issam Raad

Publication year - 2007

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/dkm506

Subject(s) - linezolid , medicine , gastroenterology , concomitant , pancytopenia , chemotherapy , cancer , creatinine , bone marrow , vancomycin , biology , bacteria , genetics , staphylococcus aureus

Linezolid is the first approved synthetic oxazolidinone with activity against multidrug-resistant gram-positive pathogens. However, haematological toxic effects of linezolid frequently limit its prolonged use, especially in patients with poor marrow reserves such as those with cancer receiving chemotherapy. Previous authors have reported that administration of vitamin B6 with linezolid reversed pancytopenia in two patients.

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