Analysis of in vitro activities and modes of action of synthetic antimicrobial peptides derived from an α-helical ‘sequence template’ | Zendy

Ulrike Pag | Zendy; M. Oedenkoven | Zendy; V. P. SASS | Zendy; Yechiel Shai | Zendy; Olga V. Shamova | Zendy; Nikolinka Antcheva | Zendy; Alessandro Tossi | Zendy; HansGeorg Sahl | Zendy

Open Access

Analysis of in vitro activities and modes of action of synthetic antimicrobial peptides derived from an α-helical ‘sequence template’

Author(s) -

Ulrike Pag,

M. Oedenkoven,

V. P. SASS,

Yechiel Shai,

Olga V. Shamova,

Nikolinka Antcheva,

Alessandro Tossi,

HansGeorg Sahl

Publication year - 2008

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/dkm479

Subject(s) - antimicrobial peptides , biology , efflux , antimicrobial , staphylococcus aureus , cell membrane , depolarization , biochemistry , bacteria , innate immune system , microbiology and biotechnology , membrane , biophysics , genetics , receptor

Cationic antimicrobial peptides (AMPs) are indispensable components of innate immune systems and promising candidates for novel anti-infective strategies. We rationally designed a series of peptides based on a template derived from known alpha-helical AMPs, which were then analysed regarding efficacy against clinical isolates and antibiotic mechanisms.

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