Continuous versus intermittent infusion of temocillin, a directed spectrum penicillin for intensive care patients with nosocomial pneumonia: stability, compatibility, population pharmacokinetic studies and breakpoint selection | Zendy

Raf De Jongh | Zendy; Ria Hens | Zendy; Violetta Basma | Zendy; Johan W. Mouton | Zendy; Paul M. Tulkens | Zendy; Stéphane Carryn | Zendy

Open Access

Continuous versus intermittent infusion of temocillin, a directed spectrum penicillin for intensive care patients with nosocomial pneumonia: stability, compatibility, population pharmacokinetic studies and breakpoint selection

Author(s) -

Raf De Jongh,

Ria Hens,

Violetta Basma,

Johan W. Mouton,

Paul M. Tulkens,

Stéphane Carryn

Publication year - 2007

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/dkm467

Subject(s) - pharmacokinetics , medicine , pharmacodynamics , penicillin , pneumonia , broad spectrum , intensive care medicine , antibiotics , ventilator associated pneumonia , intensive care , population pharmacokinetics , population , pharmacology , intensive care unit , microbiology and biotechnology , biology , chemistry , environmental health , combinatorial chemistry

Temocillin, a 6alpha-methoxy-penicillin stable towards most beta-lactamases (including extended-spectrum beta-lactamase), is presented as an alternative to carbapenems for susceptible Enterobacteriaceae in microbiological surveys. We aimed at documenting its potential clinical usefulness in intensive care (IC) patients using pharmacokinetic/pharmacodynamic approaches applied to conventional (twice daily) and continuous infusion (CI) modes of administration.

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