Azole antifungals induce up-regulation of SAP4, SAP5 and SAP6 secreted proteinase genes in filamentous Candida albicans cells in vitro and in vivo | Zendy

Caroline J. Barelle | Zendy; Vanessa M.S. Duncan | Zendy; Alistair J. P. Brown | Zendy; Neil A. R. Gow | Zendy; Frank C. Odds | Zendy

Open Access

Azole antifungals induce up-regulation of SAP4, SAP5 and SAP6 secreted proteinase genes in filamentous Candida albicans cells in vitro and in vivo

Author(s) -

Caroline J. Barelle,

Vanessa M.S. Duncan,

Alistair J. P. Brown,

Neil A. R. Gow,

Frank C. Odds

Publication year - 2007

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/dkm456

Subject(s) - candida albicans , green fluorescent protein , biology , microbiology and biotechnology , virulence , corpus albicans , in vitro , in vivo , fluconazole , fluorescence microscope , hypha , gene , biochemistry , fluorescence , antifungal , physics , quantum mechanics

Expression of fungal virulence factors can be influenced by exposure to antifungal agents. To test this hypothesis, we determined the effects of subinhibitory concentrations of three antifungal agents on expression of three secreted proteinase genes associated with virulence in filamentous forms of Candida albicans.

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