Effect of severity of sepsis on tissue concentrations of linezolid | Zendy

Christiane Thallinger | Zendy; C. Buerger | Zendy; Nele Plock | Zendy; S. Kljucar | Zendy; Sonja Wuenscher | Zendy; Robert Sauermann | Zendy; Charlotte Kloft | Zendy; Christian Joukhadar | Zendy

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Effect of severity of sepsis on tissue concentrations of linezolid

Author(s) -

Christiane Thallinger,

C. Buerger,

Nele Plock,

S. Kljucar,

Sonja Wuenscher,

Robert Sauermann,

Charlotte Kloft,

Christian Joukhadar

Publication year - 2007

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/dkm431

Subject(s) - linezolid , sepsis , pharmacokinetics , medicine , septic shock , dosing , shock (circulatory) , pharmacodynamics , intensive care medicine , anesthesia , vancomycin , staphylococcus aureus , biology , bacteria , genetics

In the present study, we examined whether differences in the severity of sepsis translate to differences in the pharmacokinetic profile of linezolid in plasma and the interstitium of target tissues after a single intravenous dose of 600 mg by means of the microdialysis technique.

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