Open AccessMarA-mediated overexpression of the AcrAB efflux pump results in decreased susceptibility to tigecycline in Escherichia coli
Author(s) -
David Keeney,
Alexey Ruzin,
Fionnuala McAleese,
Ellen Murphy,
Patricia A. Bradford
Publication year - 2007
Publication title -
journal of antimicrobial chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.124
H-Index - 194
eISSN - 1460-2091
pISSN - 0305-7453
DOI - 10.1093/jac/dkm397
Subject(s) - biology , transposon mutagenesis , transposable element , escherichia coli , tigecycline , efflux , microbiology and biotechnology , insertion sequence , mutant , plasmid , gene , genetics , antibiotics
The purpose of this study was to characterize decreased susceptibility to tigecycline in clinical isolates of Escherichia coli obtained during Phase 3 clinical trials.
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