Stearylamine-bearing cationic liposomes kill Leishmania parasites through surface exposed negatively charged phosphatidylserine | Zendy

Saumyabrata Banerjee | Zendy; Jayeeta Roychoudhury | Zendy; Nahid Ali | Zendy

Open Access

Stearylamine-bearing cationic liposomes kill Leishmania parasites through surface exposed negatively charged phosphatidylserine

Author(s) -

Saumyabrata Banerjee,

Jayeeta Roychoudhury,

Nahid Ali

Publication year - 2007

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/dkm396

Subject(s) - phosphatidylserine , liposome , leishmania , cationic polymerization , microbiology and biotechnology , chemistry , biology , parasite hosting , membrane , biochemistry , phospholipid , world wide web , computer science , organic chemistry

Lipid-associated formulations of antileishmanial agents have proved to be more effective therapies with reduced toxicities. Previous studies from our group and others revealed that liposomes bearing phosphatidylcholine and stearylamine (SA) themselves kill Leishmania and other protozoan parasites in vitro and in vivo, without causing any adverse effect on host. In the present study, we offer detailed insights into the mechanism of action of these liposomes.

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