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To investigate the correlation between in vitro activity and in vivo efficacy of broad-spectrum beta-lactams for treating experimental infections due to Escherichia coli expressing two types of plasmid-mediated AmpC-type beta-lactamases, LAT-1 and FOX-1.

Broad-spectrum -lactams for treating experimental peritonitis in mice due to Escherichia coli producing plasmid-encoded cephalosporinases