Minocycline inhibits West Nile virus replication and apoptosis in human neuronal cells | Zendy

Martin Michaelis | Zendy; Martin Kleinschmidt | Zendy; H. W. Doerr | Zendy; Jaroslav Činátl | Zendy

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Minocycline inhibits West Nile virus replication and apoptosis in human neuronal cells

Author(s) -

Martin Michaelis,

Martin Kleinschmidt,

H. W. Doerr,

Jaroslav Činátl

Publication year - 2007

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/dkm307

Subject(s) - west nile virus , minocycline , apoptosis , virology , replication (statistics) , virus , viral replication , biology , neuroscience , microbiology and biotechnology , genetics , antibiotics

West Nile virus (WNV) infection causes severe meningitis and encephalitis in a subset of patients. WNV-induced apoptosis has been suggested to contribute to WNV pathogenesis. Tetracyclines exert antiviral effects against HIV and inhibit apoptosis in different models of neuronal disease. Here, the effects of the tetracyclines minocycline, demeclocycline and chlortetracycline were observed on WNV replication and WNV-induced apoptosis in different human CNS-derived cell types (primary human brain neurons, primary human retinal pigment epithelial cells and T98G human glioma cell line).

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