Disposition of linezolid in the isolated rat lung after systemic and pulmonary drug delivery | Zendy

María José de Jesús Valle | Zendy; N. S. Uranga | Zendy; Francísco González López | Zendy; Alfonso Domínguez-Gil Hurlé | Zendy; Amparo Sánchez Navarro | Zendy

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Disposition of linezolid in the isolated rat lung after systemic and pulmonary drug delivery

Author(s) -

María José de Jesús Valle,

N. S. Uranga,

Francísco González López,

Alfonso Domínguez-Gil Hurlé,

Amparo Sánchez Navarro

Publication year - 2007

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/dkm306

Subject(s) - linezolid , medicine , lung , systemic circulation , distribution (mathematics) , respiratory system , drug , respiratory disease , disposition , pharmacology , anesthesia , biology , staphylococcus aureus , vancomycin , bacteria , psychology , social psychology , mathematical analysis , mathematics , genetics

To characterize the distribution of linezolid in lung when it accesses this organ from the systemic circulation and when administered through the pulmonary route and to evaluate the influence of the 'respiratory mode' in the pulmonary distribution for both routes.

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