Investigation of conditions involved in the susceptibility of the dermatophyte Trichophyton rubrum to photodynamic treatment
Author(s) -
Threes G. M. Smijs,
J.A. Bouwstra,
M. Talebi,
S. Pavel
Publication year - 2007
Publication title -
journal of antimicrobial chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.124
H-Index - 194
eISSN - 1460-2091
pISSN - 0305-7453
DOI - 10.1093/jac/dkm304
Subject(s) - photodynamic therapy , trichophyton rubrum , singlet oxygen , ex vivo , sodium azide , chemistry , in vivo , reactive oxygen species , photochemistry , oxygen , in vitro , biochemistry , microbiology and biotechnology , biology , organic chemistry , antifungal
Photodynamic treatment (PDT) refers to a treatment with light-activated agents (photosensitizers) in combination with visible light and molecular oxygen. Recently, we have demonstrated that the porphyrins, 5,10,15-tris(4-methylpyridinium)-20-phenyl-[21H,23H]-porphine trichloride (Sylsens B) and deuteroporphyrin monomethylester (DP mme) are excellent photosensitizers to be used against Trichophyton rubrum both in vitro and ex vivo.
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