Antimalarial pharmacodynamics and pharmacokinetics of a third-generation antifolate JPC2056 in cynomolgus monkeys using an in vivo in vitro model | Zendy

Michael D. Edstein | Zendy; Barbara Kotecka | Zendy; Arba L. Ager | Zendy; Kirsten S. Smith | Zendy; Charles A. DiTusa | Zendy; Damaris Diaz | Zendy; Dennis E. Kyle | Zendy; Guy A. Schiehser | Zendy; David P. Jacobus | Zendy; Karl H. Rieckmann | Zendy; Michael T. O’Neil | Zendy

Open Access

Antimalarial pharmacodynamics and pharmacokinetics of a third-generation antifolate JPC2056 in cynomolgus monkeys using an in vivo in vitro model

Author(s) -

Michael D. Edstein,

Barbara Kotecka,

Arba L. Ager,

Kirsten S. Smith,

Charles A. DiTusa,

Damaris Diaz,

Dennis E. Kyle,

Guy A. Schiehser,

David P. Jacobus,

Karl H. Rieckmann,

Michael T. O’Neil

Publication year - 2007

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/dkm280

Subject(s) - pharmacokinetics , pharmacology , antifolate , in vivo , metabolite , pharmacodynamics , dihydrofolate reductase , plasmodium falciparum , potency , chemistry , active metabolite , biology , in vitro , methotrexate , antimetabolite , biochemistry , immunology , malaria , microbiology and biotechnology

To assess the antimalarial pharmacodynamics and pharmacokinetics of the novel dihydrofolate reductase (DHFR) inhibitor, JPC2056 and its principal active metabolite JPC2067 in cynomolgus monkeys using an in vivo-in vitro model.

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