Open AccessMacrolide resistance mechanisms among Streptococcus pneumoniae isolated over 6 years of Canadian Respiratory Organism Susceptibility Study (CROSS) (1998 2004)
Author(s) -
Aleksandra Wierzbowski,
Kimberly A. Nichol,
Nancy M. Laing,
Tamiko Hisanaga,
A. Nikulin,
James A. Karlowsky,
D. J. Hoban,
George G. Zhanel
Publication year - 2007
Publication title -
journal of antimicrobial chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.124
H-Index - 194
eISSN - 1460-2091
pISSN - 0305-7453
DOI - 10.1093/jac/dkm273
Subject(s) - 23s ribosomal rna , microbiology and biotechnology , streptococcus pneumoniae , erythromycin , lincosamides , biology , macrolide antibiotics , mycoplasma pneumoniae , ribosomal rna , serotype , antibiotics , gene , genetics , medicine , rna , pneumonia , ribosome
Resistance to macrolides in Streptococcus pneumoniae arises primarily due to Erm(B) or Mef(A). Erm(B) typically confers high-level resistance to macrolides, lincosamides and streptogramin B (MLS(B) phenotype), whereas Mef(A) confers low-level resistance to macrolides only (M phenotype). The purpose of this study was to investigate the incidence of macrolide resistance mechanisms in Canadian isolates of S. pneumoniae obtained between 1998 and 2004. Furthermore, the genetic relatedness, serotype distribution and antibiotic susceptibility profile among S. pneumoniae isolates with dual erythromycin ribosomal methylase [Erm(B)] and efflux pump [Mef(A)] were analysed.
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