Differential cytotoxicity of phospholipid analogues to pathogenic Acanthamoeba species and mammalian cells | Zendy

James McBride | Zendy; Alexander B. Mullen | Zendy; K. Christine Carter | Zendy; Craig W. Roberts | Zendy

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Differential cytotoxicity of phospholipid analogues to pathogenic Acanthamoeba species and mammalian cells

Author(s) -

James McBride,

Alexander B. Mullen,

K. Christine Carter,

Craig W. Roberts

Publication year - 2007

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/dkm245

Subject(s) - acanthamoeba , phospholipid , cytotoxicity , ic50 , liposome , biology , acanthamoeba keratitis , in vitro , pharmacology , microbiology and biotechnology , chemistry , biochemistry , membrane

Previous studies have reported the ability of several phospholipid analogues to successfully inhibit the growth of Acanthamoeba species in vitro. This study tests further phospholipid analogues, either as free drug or in liposomal formulations, and unlike previous studies, examines their comparative toxicities to mammalian cells.

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