Concentrations in plasma, epithelial lining fluid, alveolar macrophages and bronchial mucosa after a single intravenous dose of 1.6 mg/kg of iclaprim (AR-100) in healthy men | Zendy

J. Andrews | Zendy; D. Honeybourne | Zendy; J. P. Ashby | Zendy; G. Jevons | Zendy; A.P. Fraise | Zendy; Philippe Fry | Zendy; Steve Warrington | Zendy; Stephen Hawser | Zendy; Robert A. Wise | Zendy

Open Access

Concentrations in plasma, epithelial lining fluid, alveolar macrophages and bronchial mucosa after a single intravenous dose of 1.6 mg/kg of iclaprim (AR-100) in healthy men

Author(s) -

J. Andrews,

D. Honeybourne,

J. P. Ashby,

G. Jevons,

A.P. Fraise,

Philippe Fry,

Steve Warrington,

Stephen Hawser,

Robert A. Wise

Publication year - 2007

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/dkm242

Subject(s) - streptococcus pneumoniae , moraxella catarrhalis , penicillin , microbiology and biotechnology , haemophilus influenzae , chemistry , medicine , antibacterial agent , pharmacology , antibiotics , biology

A validated microbiological assay was used to measure concentrations of iclaprim (AR-100) in plasma, bronchial mucosa (BM), alveolar macrophages (AM) and epithelial lining fluid (ELF) after a single 1.6 mg/kg intravenous 60 min iv infusion of iclaprim.

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