Potent and selective inhibitors of Staphylococcus epidermidis tryptophanyl-tRNA synthetase | Zendy

Yang Wu | Zendy; Kunqian Yu | Zendy; Bin Xu | Zendy; Lili Chen | Zendy; XiangLong Chen | Zendy; Jialing Mao | Zendy; Antoine Danchin | Zendy; Xu Shen | Zendy; Di Qu | Zendy; Hualiang Jiang | Zendy

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Potent and selective inhibitors of Staphylococcus epidermidis tryptophanyl-tRNA synthetase

Author(s) -

Yang Wu,

Kunqian Yu,

Bin Xu,

Lili Chen,

XiangLong Chen,

Jialing Mao,

Antoine Danchin,

Xu Shen,

Di Qu,

Hualiang Jiang

Publication year - 2007

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/dkm229

Subject(s) - staphylococcus epidermidis , microbiology and biotechnology , antibiotics , opportunistic pathogen , pathogen , biofilm , staphylococcus aureus , transfer rna , biology , bacteria , biochemistry , rna , pseudomonas aeruginosa , genetics , gene

The skin commensal and opportunistic pathogen Staphylococcus epidermidis is one of the leading causes of nosocomial and biofilm-associated infections, which urgently requires discovery of new antibiotics. We decided to find new leads that target the S. epidermidis tryptophanyl-tRNA synthetase (SeWRS), which is essential for translation.

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