Emergence and maintenance of resistance to fluoroquinolones and coumarins in Staphylococcus aureus: predictions from in vitro studies | Zendy

Anna Vickers | Zendy; Alex J. O’Neill | Zendy; I. Chopra | Zendy

Open Access

Emergence and maintenance of resistance to fluoroquinolones and coumarins in Staphylococcus aureus: predictions from in vitro studies

Author(s) -

Anna Vickers,

Alex J. O’Neill,

I. Chopra

Publication year - 2007

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/dkm191

Subject(s) - dna gyrase , topoisomerase iv , biology , staphylococcus aureus , microbiology and biotechnology , mutant , topoisomerase , novobiocin , antibiotics , dna , genetics , gene , escherichia coli , bacteria

Fluoroquinolones and coumarins interfere with the activity of bacterial type II topoisomerase enzymes. We examined the development of resistance to these agents in Staphylococcus aureus and determined the effect of simultaneous topoisomerase IV and DNA gyrase mutations on the biological fitness of the organism. This work aimed to gain insight into how such mutants might arise and survive in the clinical environment.

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