Decreased affinity of mosaic-structure recombinant penicillin-binding protein 2 for oral cephalosporins in Neisseria gonorrhoeae | Zendy

Susumu Ochiai | Zendy; Satomi Sekiguchi | Zendy; Akio Hayashi | Zendy; Mitsunobu Shimadzu | Zendy; Hiroaki Ishiko | Zendy; Rie MatsushimaNishiwaki | Zendy; Osamu Kozawa | Zendy; Mitsuru Yasuda | Zendy; Takashi Deguchi | Zendy

Open Access

Decreased affinity of mosaic-structure recombinant penicillin-binding protein 2 for oral cephalosporins in Neisseria gonorrhoeae

Author(s) -

Susumu Ochiai,

Satomi Sekiguchi,

Akio Hayashi,

Mitsunobu Shimadzu,

Hiroaki Ishiko,

Rie MatsushimaNishiwaki,

Osamu Kozawa,

Mitsuru Yasuda,

Takashi Deguchi

Publication year - 2007

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/dkm166

Subject(s) - neisseria gonorrhoeae , cephalosporin , cefixime , microbiology and biotechnology , penicillin , cefdinir , recombinant dna , penicillin binding proteins , ceftriaxone , biology , antibiotics , biochemistry , gene

In Neisseria gonorrhoeae, the mosaic structure of penicillin-binding protein 2 (PBP 2), composed of fragments of PBP 2 from Neisseria cinerea and Neisseria perflava, was significantly associated with decreased susceptibility to cephalosporins, particularly oral cephalosporins. The aim of this study was to determine the affinity of mosaic PBP 2 for cephalosporins in N. gonorrhoeae.

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