AI-2 quorum sensing affects antibiotic susceptibility in Streptococcus anginosus | Zendy

Nibras A. A. M. Ahmed | Zendy; Fernanda C. Petersen | Zendy; Anne Aamdal Scheie | Zendy

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AI-2 quorum sensing affects antibiotic susceptibility in Streptococcus anginosus

Author(s) -

Nibras A. A. M. Ahmed,

Fernanda C. Petersen,

Anne Aamdal Scheie

Publication year - 2007

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/dkm124

Subject(s) - streptococcus anginosus , microbiology and biotechnology , quorum sensing , ampicillin , antibiotics , mutant , biology , antimicrobial , erythromycin , streptococcus pyogenes , antibiotic resistance , biofilm , bacteria , streptococcus , genetics , gene , staphylococcus aureus

The concern over rising antibiotic resistance necessitates exploration of alternative approaches in antimicrobial therapy. Bacterial communities use the auto-inducer 2 (AI-2) quorum sensing signal at a specific threshold level for intra- and interspecies communication in order to regulate virulence behaviour. AI-2 signal production occurs in bacteria that possess a luxS homologue. In this study, we investigate for the first time the association between AI-2 signalling and susceptibility to antibiotics.

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