Molecular mechanisms of resistance to antibiotics in Bartonella bacilliformis | Zendy

Silpak Biswas | Zendy; Didier Raoult | Zendy; JeanMarc Rolain | Zendy

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Molecular mechanisms of resistance to antibiotics in Bartonella bacilliformis

Author(s) -

Silpak Biswas,

Didier Raoult,

JeanMarc Rolain

Publication year - 2007

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/dkm105

Subject(s) - microbiology and biotechnology , biology , antibiotics , erythromycin , rifampicin , ciprofloxacin , quinolone , aminoglycoside , dna gyrase , antibacterial agent , nalidixic acid , genetics , gene , escherichia coli

Bartonella bacilliformis is the aetiological agent of Carrion's disease. Although ciprofloxacin, rifampicin and erythromycin have been successfully used in the treatment of the disease, failures and relapses have been reported. The objective of our study was to select in vitro mutants resistant to antibiotics in order to determine the frequency of mutations and to characterize the mechanism of resistance at the molecular level.

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