Pharmacokinetic modelling of a once-daily dosing regimen for intravenous tobramycin in paediatric cystic fibrosis patients | Zendy

Wallace Lam | Zendy; James Tjon | Zendy; Winnie Seto | Zendy; A. Dekker | Zendy; Cecile Wong | Zendy; Eshetu G. Atenafu | Zendy; Ari Bitnun | Zendy; Valerie Waters | Zendy; Yvonne Yau | Zendy; Melinda Solomon | Zendy; Félix Ratjen | Zendy

Open Access

Pharmacokinetic modelling of a once-daily dosing regimen for intravenous tobramycin in paediatric cystic fibrosis patients

Author(s) -

Wallace Lam,

James Tjon,

Winnie Seto,

A. Dekker,

Cecile Wong,

Eshetu G. Atenafu,

Ari Bitnun,

Valerie Waters,

Yvonne Yau,

Melinda Solomon,

Félix Ratjen

Publication year - 2007

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/dkm097

Subject(s) - tobramycin , dosing , cystic fibrosis , medicine , pharmacokinetics , regimen , exacerbation , anesthesia , antibiotics , gentamicin , microbiology and biotechnology , biology

This study was designed to determine an optimal dose range for the once-daily dosing (ODD) of tobramycin in the treatment of an acute pulmonary exacerbation in paediatric cystic fibrosis (CF) patients. In addition, we aimed to assess whether certain patient characteristics affect tobramycin pharmacokinetics and, therefore, dosing.

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