Evaluation of the in vivo efficacy of topical tobramycin against Pseudomonas sinonasal biofilms | Zendy

Alexander G. Chiu | Zendy; Marcelo B. Antunes | Zendy; James N. Palmer | Zendy; Noam A. Cohen | Zendy

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Evaluation of the in vivo efficacy of topical tobramycin against Pseudomonas sinonasal biofilms

Author(s) -

Alexander G. Chiu,

Marcelo B. Antunes,

James N. Palmer,

Noam A. Cohen

Publication year - 2007

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/dkm087

Subject(s) - tobramycin , microbiology and biotechnology , biofilm , saline , antibiotics , sinusitis , pseudomonas aeruginosa , medicine , lumen (anatomy) , mucous membrane of nose , bacteria , gentamicin , biology , pathology , surgery , genetics

There is increasing evidence that bacterial biofilms are present within the sinonasal mucosa of patients with medically recalcitrant chronic rhinosinusitis. The antibiotic concentrations needed to eradicate biofilms are much higher than those commonly used and pose an increased risk for systemic side effects. Topical medications are an alternative approach to deliver high concentrations to the mucosa while limiting systemic side effects. This is the first study to evaluate the effects of a topical antibiotic on Pseudomonas biofilms in an animal model of sinusitis.

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