Clarithromycin has an immunomodulatory effect on ERK-mediated inflammation induced by Pseudomonas aeruginosa flagellin | Zendy

Masaharu Shinkai | Zendy; Yolanda S. López-Boado | Zendy; Bruce K. Rubin | Zendy

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Clarithromycin has an immunomodulatory effect on ERK-mediated inflammation induced by Pseudomonas aeruginosa flagellin

Author(s) -

Masaharu Shinkai,

Yolanda S. López-Boado,

Bruce K. Rubin

Publication year - 2007

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/dkm084

Subject(s) - flagellin , secretion , kinase , mapk/erk pathway , biology , microbiology and biotechnology , immune system , interleukin 8 , protein kinase a , inflammation , biochemistry , immunology , receptor

Pseudomonas aeruginosa exoproducts are potent triggers of immune responses in eukaryotic cells. Clarithromycin initially decreases, then increases and finally produces a sustained suppression of interleukin (IL)-8 secretion from normal human bronchial epithelial (NHBE) cells through inhibition and activation of extracellular signal-regulated kinase (ERK). This polyphasic immune response is referred to as immunomodulation.

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