Effects of dosing regimen on accumulation, retention and prophylactic efficacy of liposomal amphotericin B | Zendy

Peter J. Smith | Zendy; Jon Olson | Zendy; David Constable | Zendy; Julie Schwartz | Zendy; Richard T. Proffitt | Zendy; Jill AdlerMoore | Zendy

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Effects of dosing regimen on accumulation, retention and prophylactic efficacy of liposomal amphotericin B

Author(s) -

Peter J. Smith,

Jon Olson,

David Constable,

Julie Schwartz,

Richard T. Proffitt,

Jill AdlerMoore

Publication year - 2007

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/dkm077

Subject(s) - amphotericin b , spleen , candida albicans , pharmacology , kidney , dosing , biodistribution , antifungal drug , medicine , drug , pharmacokinetics , immunology , biology , in vivo , microbiology and biotechnology , antifungal

We hypothesized that effective prophylactic treatment of fungal infections would require adequate drug penetration and retention at potential infection sites. Using a mouse model, we examined liposomal amphotericin B (L-AmB) biodistribution, cell localization and retention in kidneys, lungs, liver and spleen to evaluate effective dosing regimens for prophylaxis of Candida glabrata and Candida albicans infections.

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